Building Value Since 1965

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The Family

Plasma therapies were developed during the 2nd World War to treat battlefield casualties, however during peace time there was no reliable source of human plasma to manufacture life-saving drugs. In the late 60s, Dr. Austin R. Stough formed Stough Enterprises, Inc (SEI) and began developing off-street plasma donor facilities to meet this demand. Contracts were formed early on with Hyland Laboratories of Oak Park, IL and Cutter Laboratories of Berkeley, CA. Stough Enterprises expanded rapidly and at Dr. Stough’s death in 1972, was a recognized leader in the operation of commercial plasmapheresis centers.

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The Beginnings of Commercial Plasma

The 1970s saw continued expansion of Stough Enterprises. Betty Stough, Dr. Stough’s widow, and her son-in-law, Bob Van Schuyver, took over plasma operations. Michael Stough joined the firm in 1975 and accepted the position of CEO in 1980. The firm grew to 8 plasmapheresis centers, with approximately 125 employees and $12 million in sales. Becoming active in the production of tetanus and hyperimmune plasma, SEI began plasma sales on an international basis with clients in Spain, Austria and Germany.

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Diversification into Real Estate

With the beginning of the AIDS epidemic, the 80s were a very turbulent time in the plasma industry. In 1983, Dr. Gallo developed a reliable test for HIV. SEI was the first commercial plasmapheresis company in the United States to test for the AIDS virus. Manufacturing techniques were developed to eliminate the possibility of a viral infection from plasma products. During this time Michael Stough also began pursuing real estate development, principally strip shopping centers and downtown commercial buildings.

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Hanke Building is saved and renovated; 1st Prototype of a plasma center is developed

Michael Stough forms a subsidiary, Stough Development, and begins to shift his focus to real estate development, including historic building renovation, retail development, strip shopping centers and office space. The plasma industry continued to become more sophisticated and brought about the development of intravenous immune globulins, an extremely important therapy for people with compromised immune systems.

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Consolidation of Industries; Sale of Operations

The 2000s brought an explosion of growth in the supply and demand for plasma derived products. Stough Enterprises doubled their size of plasma operations to 15 centers, over 500 employees, and $50 million in annual sales. In 2006, SEI plasma operations were sold to the international company, Grifols, and Michael Stough focuses his concentration on real estate development.

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Scott Stough, son of CEO Michael Stough, comes to work for the business.

In 2010 Scott Stough, son of CEO Michael Stough, comes to work for the business, making him the third generation to work in the family business. The plasma pharmaceutical industry begins vertical integration and large pharmaceutical corporations start acquiring smaller plasma operators. This initiates a period of rapid expansion of plasma centers. With Stough’s 40 years of experience in plasma operations and 25 years of medical facility construction they are now recognized as an industry leader in developing plasmapheresis facilities.


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To streamline delivery and control costs, we take a prototype approach when possible, engage local civil engineering consultants for each project, establish a working relationship.